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Typically, the medications are administered through intravenous (IV) therapy

Glutamate dehydrogenase hyperinsulinism (GDH-HI) is the second most common type of CHI and is caused by mutations in the glutamate dehydrogenase 1 gene

However, their variable BBB permeability and non-selective action often result in side effects such as neuropsychiatric issues and impulse control disorders 55,56,57

503A compounding pharmacies require monitoring every 6 months and 503B facilities have a robust monitoring program that is developed and performed every shift

Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS

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